It's not as bad a job as it looks. I bought a '94 C4 a year ago that ran rough so I did a tune up that included the plugs. The only one that was really difficult was the passenger side rear. I had trouble getting my hands in between the exhaust manifold and the A/C coil housing. But I was able to do it with help from the wife and her smaller hands.
One big tip that I can give you, especially on the driver's side, is to jack the car up, support it on a jack stand, remove the wheel and the fender liner section behind the wheel. With that out of the way with a long socket extension you can get in "under" some of the things like the ASR control module and the brake master cylinder.
Make sure you use a torque wrench to tighten the replacement plugs as you don't want to take the chance of over tightening the plugs in the aluminum heads.
The rear on the passenger side I found it useful to have a spark plug socket that has a hex at the top end so that I could put a box wrench over the hex to loosen the plug. There was not enough room for the ratchet handle, it would hit against the A/C coil housing as the plug screwed outward.
Enjoy your Vette!
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Bob - '94 Polo Green Coupe